Population
Dogs (normal unblocked, and blocked animals)
Comparison
Methoxamine injection or infusion vs l-epinephrine, l-norepinephrine, and…
Design
Preclinical
Authors
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Methoxamine may precipitate ventricular failure via afterload in canines; leaves open translation to human vasoconstrictor use in shock.
In a canine model, methoxamine produces peripheral vasoconstriction without a positive inotropic effect, leading to increased peripheral resistance and atrial pressures that can culminate in ventricular failure.
Brewster et al. (1960) studied this question.
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