Key result
Normethanephrine (10-5M) increased the outflow of noradrenaline on nerve stimulation by about 25% in the perfused rabbit heart, indicating extra-neuronal uptake plays a role in transmitter inactivation.
Population
Sympathetically stimulated, perfused rabbit heart
Comparison
Normethanephrine and desmethylimipramine vs Baseline (before inhibition) or lower doses
Design
Preclinical
Authors
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Extra-neuronal uptake modestly modulates noradrenaline in rabbit heart; leaves open human relevance and should not yet change practice.
Extra-neuronal uptake of noradrenaline plays a small but significant role in the inactivation of the transmitter from neuro-effector junctions in the rabbit heart.
Junstad et al. (1973) studied Perfused rabbit heart. Normethanephrine vs. Lower doses / baseline was evaluated on Outflow of noradrenaline on nerve stimulation. Normethanephrine (10-5M) increased the outflow of noradrenaline on nerve stimulation by about 25% in the perfused rabbit heart, indicating extra-neuronal uptake plays a role in transmitter inactivation.
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