Population
Isolated rabbit heart
Comparison
Noradrenaline reuptake inhibitors and… vs Comparison between different reuptake inhibitors
Design
Preclinical
Authors
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Caution against clinical extrapolation from rabbit heart; leaves open in vivo release mechanisms in intact systems.
Certain noradrenaline reuptake inhibitors (protriptyline, phenoxybenzamine, LU 3-010) not only block reuptake but also augment the amount of noradrenaline released from nerves in the isolated rabbit heart.
Åke Wennmalm (1971) studied this question.
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