Key result
Inhibition of prostaglandin synthesis increased the relative outflow of noradrenaline by about 90% during 2 Hz nerve stimulation, but had no significant influence at 10 Hz.
Population
Isolated perfused, sympathetically innervated rabbit heart
Comparison
Infusion of 5, 8, 11, 14-eicosatetraynoic acid… vs Nerve stimulation without the inhibitor
Design
Preclinical
Follow-up
6 min
Authors
Loading...
Prostaglandin inhibition of noradrenaline release appears frequency-dependent in this animal model; leaves open relevance to human sympathetic regulation.
Prostaglandin-mediated inhibition of sympathetic transmitter release is more efficient at lower, physiological nerve impulse frequencies.
Junstad et al. (1973) studied this question. 5, 8, 11, 14-eicosa tetranyoic acid was evaluated on Outflow of noradrenaline. Inhibition of prostaglandin synthesis increased the relative outflow of noradrenaline by about 90% during 2 Hz nerve stimulation, but had no significant influence at 10 Hz.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: