Key result
Sympathetic nerve stimulation of isolated guinea pig lungs evoked exclusive noradrenaline release, which was significantly reduced in unventilated preparations and increased at higher perfusion rates.
Population
Isolated guinea pig lungs
Comparison
Sympathetic nerve stimulation under varied… vs Unventilated vs ventilated preparations…
Design
Preclinical
Authors
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Hypothesis-generating for pulmonary sympathetic control; leaves open in vivo relevance and clinical translation.
Noradrenaline is the exclusive catecholamine released from pulmonary vasculature during sympathetic stimulation, and its release is modulated by ventilation and perfusion flow rates.
Yamane et al. (1999) studied this question. Sympathetic nerve stimulation under varied ventilation and perfusion vs. Unventilated preparations and different perfusion flow rates was evaluated on Noradrenaline efflux. Sympathetic nerve stimulation of isolated guinea pig lungs evoked exclusive noradrenaline release, which was significantly reduced in unventilated preparations and increased at higher perfusion rates.
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