Population
Rat, guinea pig, and human cardiac tissue (perfused hearts and incubated human atrial tissue)
Comparison
Myocardial ischemia, anoxia, acidosis, and… vs Control electrical field stimulation prior to…
Design
Preclinical
Authors
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Species differences in ischemia-induced noradrenaline release caution rodent-to-human extrapolation; leaves open species-specific autonomic mechanisms in cardiac ischemia.
Myocardial ischemia and its metabolic components exert species-dependent effects on exocytotic noradrenaline release in cardiac tissue.
Seyfarth et al. (1993) studied this question.
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