Why the study?
Does activation of pulmonary chemosensitive sympathetic afferent fibers induce an excitatory pressor reflex in rats?
Population
Anesthetized, bilaterally vagotomized, adult Sprague-Dawley rats
Design
Preclinical
Follow-up
9-10 weeks post-RTX
Key result
Application of bradykinin and capsaicin to the visceral pleura of the lung in vagotomized rats produced an excitatory pressor reflex, increasing MAP, HR, and RSNA.
Authors
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May explain autonomic responses in pulmonary inflammation; hypothesis-generating in rats, human relevance untested.
Does activation of pulmonary chemosensitive sympathetic afferent fibers induce an excitatory pressor reflex in rats?
Activation of pulmonary chemosensitive sympathetic afferents induces an excitatory pressor reflex, suggesting a mechanism for autonomic responses in pulmonary inflammation.
Shanks et al. (2018) studied this question. Bradykinin and capsaicin application was evaluated on Changes in renal sympathetic nerve activity (RSNA) and hemodynamics. Application of bradykinin and capsaicin to the visceral pleura of the lung in vagotomized rats produced an excitatory pressor reflex, increasing MAP, HR, and RSNA.