Key result
Intra-atrial administration of saline or phenylbiguanide in rats elicited excitatory or inhibitory responses in 38 NTS neurons, accompanied by reflex decreases in blood pressure and heart rate.
Population
Male rats (350 to 425 g), anesthetized, paralyzed, and subjected to bilateral sinoaortic denervation
Design
Preclinical, random sequence of administration
Authors
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Cardiopulmonary receptor stimulation shapes rat NTS responses and reflexes; leaves open translation to human cardiovascular control.
Stimulation of mechanically and chemically sensitive receptors in the heart and lung elicits distinct excitatory or inhibitory responses in NTS neurons and corresponding reflex cardiovascular changes in rats.
Hines et al. (1994) studied this question. Intra-atrial saline or phenylbiguanide was evaluated on Extracellular activity of neurons in the nucleus tractus solitarius (NTS) and changes in MAP, RASP, HR, and RSNA. Intra-atrial administration of saline or phenylbiguanide in rats elicited excitatory or inhibitory responses in 38 NTS neurons, accompanied by reflex decreases in blood pressure and heart rate.
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