Why the study?
Does microinjection of ATP into the NTS alter respiratory and autonomic responses in the working heart-brainstem preparation of the rat?
Population
Working heart-brainstem preparation from young male Wistar rats, n=12
Comparison
Microinjections of increasing doses of ATP into… vs Baseline
Design
Preclinical
Authors
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Hypothesis-generating for NTS ATP in rodent chemoreflex; leaves open human autonomic translation.
Does microinjection of ATP into the NTS alter respiratory and autonomic responses in the working heart-brainstem preparation of the rat?
ATP microinjection into distinct subregions of the NTS produces different respiratory and autonomic responses, suggesting ATP in the caudal NTS is involved in the respiratory but not the sympathoexcitatory component of the chemoreflex.
Antunes et al. (2005) studied this question.
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