October 1, 1997Clinical and Experimental Pharmacology and Physiology

Purines and the Nucleus Tractus Solitarius: Effects on Cardiovascular and Respiratory Function

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Population

Experimental models for evaluating cardiorespiratory regulation by the nucleus tractus solitarius (NTS)

Design

Preclinical

Authors

JPJW PhillisWayne State University TSTJ ScisloWayne State University DOD. S. O'LearyWayne State University

Discussion

Member takes

Implication

Rodent findings should not change practice; extends mechanistic understanding of purinergic NTS control in animals.

Structured PICO

Population

Experimental models for evaluating cardiorespiratory regulation by the nucleus tractus solitarius (NTS)

Intervention

Micro-injections of selective agonists and antagonists of purinoceptors (adenosine, ATP, CGS21680, CPA, alpha, beta-methylene ATP) into the NTS

Outcome

Changes in heart rate, arterial blood pressure, respiratory frequency, vascular conductance, and sympathetic nerve activitysurrogate

Adenosine and ATP play distinct modulatory and neurotransmitter roles in the nucleus tractus solitarius to regulate cardiovascular and respiratory functions.

Cite This Study

Phillis et al. (1997) studied this question.

synapsesocial.com/papers/6a71c9bf6ceb2bbd16e03b60 https://doi.org/10.1111/j.1440-1681.1997.tb02124.x

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Purines and the Nucleus Tractus Solitarius: Effects on Cardiovascular and Respiratory Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Purines and the Nucleus Tractus Solitarius: Effects on Cardiovascular and Respiratory Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider