January 29, 2008CirculationOpen Access

Adenosine Modulates Cardiovascular Functions Through Activation of Extracellular Signal-Regulated Kinases 1 and 2 and Endothelial Nitric Oxide Synthase in the Nucleus Tractus Solitarii of Rats

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Population

urethane-anesthetized male Sprague-Dawley rats

Design

Preclinical

Authors

WHWen-Yu HoChang Gung University PLPei‐Jung LuInstitute of Physics, Academia Sinica MHMichael HsiaoKaohsiung Medical University

Discussion

Member takes

Implication

No immediate clinical implications; extends mechanistic insight into adenosine NTS signaling via ERK1/2-eNOS in animals.

Structured PICO

Population

urethane-anesthetized male Sprague-Dawley rats

Intervention

Adenosine microinjected into the nucleus tractus solitarius (NTS), with or without prior administration of PD98059 (6 nmol/60 nL), L-NIO (6 nmol/60 nL), or vinyl-L-NIO (600 pmol/60 nL)

Outcome

Blood pressure and heart ratesurrogate

The cardiovascular modulatory effects of adenosine in the nucleus tractus solitarius are mediated by the activation of ERK1/2 and subsequent endothelial NOS phosphorylation.

Cite This Study

Ho et al. (2008) studied this question.

synapsesocial.com/papers/6a8543e6f76e40547ac2b18f https://doi.org/10.1161/circulationaha.107.746032

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Adenosine Modulates Cardiovascular Functions Through Activation of Extracellular Signal-Regulated Kinases 1 and 2 and Endothelial Nitric Oxide Synthase in the Nucleus Tractus Solitarii of Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine Modulates Cardiovascular Functions Through Activation of Extracellular Signal-Regulated Kinases 1 and 2 and Endothelial Nitric Oxide Synthase in the Nucleus Tractus Solitarii of Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider