Observational analysis shows specific inhaled activators induce changes in respiration and heart rate, suggesting distinct roles of vagal afferent subsets.
Key Points
Inhaled activators like capsaicin and AITC significantly affect respiration and heart rate in conscious mice.
Activation of TRPV1 and AITC leads to bradypnea and greater bradycardia, highlighting their distinct physiological roles.
Chemogenetic activation of specific airway afferent subsets reveals differing effects on cardiorespiratory function.
Data indicates that diverse vagal nociceptors play unique roles in regulating respiratory and cardiovascular responses.