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December 30, 2015Journal of Applied PhysiologyOpen Access

Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin, and ATP in Sprague-Dawley rats

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Population

Sprague-Dawley (SD) rats (conscious, and paralyzed/ventilated following precollicular decerebration)

Comparison

Airway stimulation via inhalation of capsaicin… vs Baseline or administration of antagonists and…

Design

Preclinical

Key result

Inhalation of AITC, capsaicin, and ATP by conscious Sprague-Dawley rats caused significant bradycardia and AV block via reflex modulation of the autonomic nervous system.

Authors

JHJustin Shane HooperSHStephen HadleyKMKendall F. Morris

Discussion

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Overview

Pollutant-induced airway reflexes may trigger human arrhythmias; animal findings leave clinical translation open.

Structured PICO

P
Population
Sprague-Dawley (SD) rats (conscious, and paralyzed/ventilated following precollicular decerebration)
I
Intervention
Airway stimulation via inhalation of capsaicin (TRPV1 agonist), allyl isothiocyanate (AITC, TRPA1 agonist), and ATP (P2X2/3 agonist)
C
Comparator
Baseline or administration of antagonists (ruthenium red, atropine, terazosin) and anesthetics (urethane, ketamine, isoflurane)
O
Outcome
Bronchopulmonary sensory activity and cardiovascular responses (heart rate, atrioventricular block, PR intervals, blood pressure)surrogate

Activation of ion channels on nociceptive airway sensory nerves by pollutants causes significant cardiovascular effects via autonomic reflex modulation in rats.

Cite This Study

Hooper et al. (2015) studied this question. Airway stimulation with AITC, capsaicin, and ATP was evaluated on Cardiovascular responses (bradycardia, AV block, blood pressure changes). Inhalation of AITC, capsaicin, and ATP by conscious Sprague-Dawley rats caused significant bradycardia and AV block via reflex modulation of the autonomic nervous system.

synapsesocial.com/papers/6a8320745123f2a1809c8cdahttps://doi.org/10.1152/japplphysiol.00944.2015
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