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February 17, 2014Perfusion

The production of vasoconstriction-induced residual NO modulates perfusion pressure in rat mesenteric vascular bed

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Key result

In the rat mesenteric vascular bed, pressure-induced residual NO production exerts a modulatory role against vasoconstriction induced by phenylephrine.

Population

Rat perfused mesenteric bed

Comparison

Application of NO scavenger hydroxocobalamin in… vs Phenylephrine alone or with NOS inhibitors alone

Design

Preclinical

Authors

MSMA SeçilmişÖÖÖY ÖzüOKOE Kıroğlu

Discussion

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Implication

Preclinical data only; leaves open relevance of residual NO modulation to human vascular tone.

Structured PICO

P
Population
Rat perfused mesenteric bed
I
Intervention
Application of NO scavenger hydroxocobalamin (100 µM) in the presence of NOS inhibitors (L-NA or L-NAME) during phenylephrine-induced vasoconstriction
C
Comparator
Phenylephrine alone or with NOS inhibitors alone
O
Outcome
Perfusion pressuresurrogate

There is NOS inhibitor-resistant residual NO production in response to pressure in the rat mesenteric vascular bed that modulates vasoconstriction.

Cite This Study

Seçilmiş et al. (2014) studied this question. Hydroxocobalamin (HCX) and NOS inhibitors was evaluated on Perfusion pressure. In the rat mesenteric vascular bed, pressure-induced residual NO production exerts a modulatory role against vasoconstriction induced by phenylephrine.

synapsesocial.com/papers/6a706c5e22b3175134db50bdhttps://doi.org/10.1177/0267659114524263
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Also Consider

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  4. 4Endothelium-dependent hyperpolarization and relaxation resistance to NG-nitro-?-arginine and indomethacin in coronary circulation2000 · 89 citations
  5. 5An Endothelium-Derived Hyperpolarizing Factor–Like Factor Moderates Myogenic Constriction of Mesenteric Resistance Arteries in the Absence of Endothelial Nitric Oxide Synthase–Derived Nitric Oxide2001 · 85 citations