Population
Wistar rats (mesenteric resistance arteries)
Comparison
Chronic NOS inhibition and acute in vitro NOS… vs Control (untreated)
Design
Preclinical
Follow-up
3 weeks (for chronic inhibition)
Authors
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Impairs resistance artery contractility despite hypertrophy; challenges acute NOS paradigms and leaves open in vivo relevance.
Chronic NOS inhibition down-regulates contractile responses to KCl and phenylephrine in mesenteric resistance arteries despite inducing medial hypertrophy, contrasting with the effects of acute NOS inhibition.
Dowell et al. (1996) studied this question.
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