Key result
Sustained NO synthesis inhibition with L-NNA in conscious dogs markedly increased resting total peripheral resistance (+73%) and exaggerated exercise-induced hypertension (P<0.01).
Population
Conscious dogs (in vivo) and isolated large coronary arteries (in vitro)
Comparison
N omega-nitro-L-arginine 20 mg.kg-1.d-1 for 7… vs Baseline and control dogs
Design
Preclinical
Follow-up
7 days
Authors
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NO critical for systemic (not coronary) resistance in exercising dogs; leaves open human translation and COX compensation.
p-value: p=<.01
Nitric oxide is essential for systemic but not coronary resistance vessel control, with the cyclooxygenase pathway providing compensatory coronary protection when NO synthesis is impaired.
Puybasset et al. (1996) studied Conscious dogs (animal model). L-NNA (N omega-nitro-L-arginine) vs. Before L-NNA / control dogs was evaluated on Total peripheral resistance at rest (p=<.01). Sustained NO synthesis inhibition with L-NNA in conscious dogs markedly increased resting total peripheral resistance (+73%) and exaggerated exercise-induced hypertension (P<0.01).
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