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November 1, 1997Journal of Cardiovascular Pharmacology

Prostaglandins Reduce the Contractile Responses to Noradrenaline and Angiotensin II in Canine Femoral Arteries After But Not Before Chronic Inhibition of Nitric Oxide Synthesis

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Population

Canine femoral arteries isolated from normal control dogs and from dogs after long-term inhibition of nitric…

Comparison

Graded concentrations of noradrenaline and… vs Femoral arteries from normal control dogs

Design

Preclinical

Follow-up

7 days (L-NNA treatment duration)

Authors

LPLouis PuybassetCentre National de la Recherche ScientifiqueFBFabrice BéverelliClinique Ambroise ParéJGJean‐François GiudicelliBicêtre Hospital

Discussion

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Implication

Should not change practice; extends NO-COX interaction models in canine vessels but leaves human relevance open.

Structured PICO

P
Population
Canine femoral arteries isolated from normal control dogs and from dogs after long-term inhibition of nitric oxide (NO) by N(omega)-nitro-L-arginine (L-NNA; 20 mg/kg/day for 7 days)
I
Intervention
Graded concentrations of noradrenaline (1 nM-100 microM) and angiotensin II (0.1-100 nM), with and without indomethacin
C
Comparator
Femoral arteries from normal control dogs
O
Outcome
Contractile responses (maximal contraction and sensitivity/EC50)surrogate

Long-term inhibition of NO synthesis in canine femoral arteries upregulates the cyclooxygenase pathway, leading to a hypocontractile response to noradrenaline and angiotensin II mediated by relaxing prostanoids.

Cite This Study

Puybasset et al. (1997) studied this question.

synapsesocial.com/papers/6a71368bf44fa9f079defd99https://doi.org/10.1097/00005344-199711000-00021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lack of importance of NO in β‐adrenoceptor‐mediated relaxation of large epicardial canine coronary arteries1994 · 41 citations
  2. 2Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction.1991 · 100 citations
  3. 3Role of endothelium-derived nitric oxide in the regulation of blood pressure.1989 · 1,838 citations
  4. 4Effects of Angiotensin II on Canine and Porcine Coronary Epicardial and Resistance Arteries2008 · 23 citations
  5. 5Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.1992 · 794 citations