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July 1, 1998AJP Heart and Circulatory Physiology

Nitric oxide modulates cardiac contractility and oxygen consumption without changing contractile efficiency

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Why the study?

Does modulation of nitric oxide with L-NMMA or L-arginine affect cardiac contractility and myocardial oxygen consumption in anesthetized dogs?

Population

15 alpha-chloralose-anesthetized dogs instrumented for measurements of left ventricular pressure, volume…

Comparison

Intravenous infusion of NO synthase inhibitor… vs Baseline measurements before infusion

Design

Preclinical

Authors

NSNaoyuki SutoAomori Rosai HospitalAMAtsushi MikuniyaHirosaki UniversityTOTomoyuki OkuboIbaraki Prefectural University of Health Sciences

Discussion

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Implication

Animal data extend in vitro NO effects to in vivo energetics; human relevance remains untested.

Structured PICO

Does modulation of nitric oxide with L-NMMA or L-arginine affect cardiac contractility and myocardial oxygen consumption in anesthetized dogs?

P
Population
15 alpha-chloralose-anesthetized dogs instrumented for measurements of left ventricular pressure, volume, coronary blood flow, and coronary venous oxygen saturation
I
Intervention
Intravenous infusion of NO synthase inhibitor L-NMMA (5 mg/kg, n=8) or NO substrate L-arginine (600 mg/kg, n=7)
C
Comparator
Baseline measurements before infusion
O
Outcome
Left ventricular end-systolic pressure-volume relationships (ESPVR) and the relationship between myocardial oxygen consumption (MVO2) and LV pressure-volume area (PVA)surrogate

Endogenous nitric oxide spares myocardial oxygen consumption by reducing oxygen use in excitation-contraction coupling and attenuates cardiac contractility without altering contractile efficiency.

Cite This Study

Suto et al. (1998) studied this question.

synapsesocial.com/papers/6a1c2e4fb33628da419d4866https://doi.org/10.1152/ajpheart.1998.275.1.h41
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs.1991 · 201 citations
  2. 2Low Increase in cGMP Induced by Organic Nitrates and Nitrovasodilators Improves Contractile Response of Rat Ventricular Myocytes1996 · 258 citations
  3. 3Attenuation of vasoconstriction by endogenous nitric oxide in rat caudal artery1992 · 58 citations
  4. 4Total mechanical energy of a ventricle model and cardiac oxygen consumption1979 · 433 citations
  5. 5Continuous measurement of left ventricular volume in animals and humans by conductance catheter.1984 · 904 citations