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January 1, 1992Circulation Research

Role of nitric oxide in reactive hyperemia of the guinea pig heart.

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Population

Isolated guinea pig heart model

Comparison

Brief coronary arterial occlusion and NO… vs Basal conditions and inactive stereoisomer…

Design

Preclinical

Authors

MKMilena KostićUniversity of NisJSJürgen SchraderDüsseldorf University Hospital

Discussion

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Implication

NO regulates coronary flow in guinea pig hearts; leaves open translation to human physiology or clinical practice.

Structured PICO

P
Population
Isolated guinea pig heart model
I
Intervention
Brief coronary arterial occlusion (60 seconds) and NO synthesis inhibition with nitro-L-arginine methyl ester (L-NAME, 30 microM)
C
Comparator
Basal conditions and inactive stereoisomer nitro-D-arginine methyl ester
O
Outcome
Nitric oxide (NO) formation and coronary flow response (reactive hyperemia)surrogate

Nitric oxide is an important regulator of coronary flow during reactive hyperemia and under basal conditions in the guinea pig heart.

Cite This Study

Kostić et al. (1992) studied this question.

synapsesocial.com/papers/6a859ae6e54a638bbf3d9b4dhttps://doi.org/10.1161/01.res.70.1.208
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of endothelium-derived nitric oxide in the regulation of blood pressure.1989 · 1,838 citations
  2. 2Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets1987 · 821 citations
  3. 3Regulation of Coronary Blood Flow1964 · 394 citations
  4. 4Coronary physiology1983 · 869 citations