Why the study?
Does inhibition of nitric oxide synthesis enhance noradrenergic constriction of large coronary arteries in anaesthetized dogs?
Population
Anaesthetized dogs after bilateral vagotomy and antagonism of beta-adrenoceptors
Comparison
Inhibition of nitric oxide synthase with… vs Baseline responses before L-NNA administration
Design
Preclinical
Authors
Loading...
NO inhibition augments large coronary constriction in dogs; leaves open relevance to human coronary vasomotor control.
Does inhibition of nitric oxide synthesis enhance noradrenergic constriction of large coronary arteries in anaesthetized dogs?
Endothelium-derived nitric oxide plays an important role in modulating noradrenergic vasoconstriction in coronary conductance arteries.
Woodman et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: