Why the study?
Does endothelin-1 cause stronger vasoconstriction than norepinephrine in rat mesenteric microvessels?
Does endothelin-1 cause stronger vasoconstriction than norepinephrine in rat mesenteric microvessels?
Endothelin-1 is a highly potent and long-lasting vasoconstrictor in the microcirculation compared to norepinephrine.
ET-1's greater potency in rat microvessels is hypothesis-generating; leaves open its comparative role versus NE in human disease.
The vasoconstrictor effects of endothelin-1 (ET-1) and norepinephrine (NE) were compared in the exteriorized rat mesentery in situ. ET-1 was 1,000 times more potent than NE in constricting both arterioles and venules. Vasoconstrictions induced by ET-1 lasted much longer than those caused by the catecholamine. At nonrelaxant doses, acetylcholine and sodium nitroprusside antagonized the constrictive response of microvessels to ET-1 and NE. However, larger doses of acetylcholine were necessary to inhibit the response to ET-1 than that to NE.
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Fortes et al. (1989) studied this question.
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