Population
Isolated, cannulated, first-order arterioles from skeletal muscle of rats
Comparison
Norepinephrine with endothelial denudation or… vs Intact endothelium without inhibitors
Design
Preclinical
Authors
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Highlights endothelial NO attenuation of norepinephrine vasoconstriction in rat arterioles; leaves open translation to human microvascular regulation.
In rat skeletal muscle arterioles, norepinephrine stimulates endothelial nitric oxide release via alpha1-adrenergic receptors, which attenuates vasoconstriction.
Tuttle et al. (2001) studied this question.
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