July 1, 1992Circulation Research

Interaction between microvascular alpha 1- and alpha 2-adrenoceptors and endothelium-derived relaxing factor.

View Full Paper

Ask AI

Bookmark

Population

Rat cremaster skeletal muscle model

Comparison

Inhibition of EDRF formation using NG-Monomethyl… vs Alpha 1 vs Alpha 2 adrenoceptor tone

Design

Preclinical

Authors

MOMitsumasa OhyanagiUniversity of North Carolina at Chapel Hill KNKazuhiko NishigakiAsahi University JFJames E. FaberUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Alpha2 tone may be more EDRF-dependent in animal microvessels; leaves open translation to human coronary vasomotor control.

Structured PICO

Population

Rat cremaster skeletal muscle model

Intervention

Inhibition of EDRF formation using NG-Monomethyl L-arginine (L-NMMA, 1-300 microM) or microembolization

Comparator

Alpha 1 vs Alpha 2 adrenoceptor tone (induced by norepinephrine with rauwolscine or prazosin)

Outcome

Microvascular constriction (arterioles and venules)surrogate

Endogenous EDRF release modulates basal microvascular tone, and alpha 2-adrenoceptor constriction is more sensitive than alpha 1 constriction to inhibition by EDRF.

Cite This Study

Ohyanagi et al. (1992) studied this question.

synapsesocial.com/papers/6a6f99f92fdcb5703edb4b8e https://doi.org/10.1161/01.res.71.1.188

View Full Paper

Ask AI

Bookmark