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January 1, 1990British Journal of PharmacologyOpen Access

Effects of basal and acetylcholine‐induced release of endothelium‐derived relaxing factor on contraction to α‐adrenoceptor agonists in a rabbit artery and corresponding veins

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Population

Isolated superficial blood vessels of the rabbit

Comparison

Acetylcholine, sodium nitroprusside… vs Endothelium-intact vs endothelium-denuded…

Design

Preclinical

Authors

JMJ.C. McGrathUniversity of Minnesota Medical CenterSMSandra M. MonaghanPfizer (United Kingdom)ATA.G.B. TempletonAstraZeneca (United States)

Discussion

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Implication

Animal data on EDRF warrant human validation; leaves open any clinical relevance to vascular tone.

Structured PICO

P
Population
Isolated superficial blood vessels of the rabbit (lateral saphenous vein, plantaris vein, and distal saphenous artery)
I
Intervention
Acetylcholine, sodium nitroprusside, haemoglobin, and mechanical disruption of the endothelium
C
Comparator
Endothelium-intact vs endothelium-denuded preparations
O
Outcome
Vascular relaxation and contraction responses to alpha-adrenoceptor agonists (e.g., noradrenaline, phenylephrine)surrogate

This preclinical study demonstrates that endothelium-derived relaxing factor (EDRF) has a more pronounced modulatory effect on alpha-adrenoceptor-mediated contractions in rabbit superficial veins compared to arteries.

Cite This Study

McGrath et al. (1990) studied this question.

synapsesocial.com/papers/6a83fca642ccde92f8c581fbhttps://doi.org/10.1111/j.1476-5381.1990.tb14657.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein.1987 · 155 citations
  2. 2The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation1985 · 680 citations