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November 1, 1988British Journal of PharmacologyOpen Access

Endothelium‐derived relaxing factor and the effects of acetylcholine and histamine on resistance blood vessels

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Population

Isolated perfused kidney and mesentery of the rat (n=8 for dose-response experiments)

Comparison

Vasodilators and vasoconstrictors with or… vs Control conditions without CHAPS or EDRF…

Design

Preclinical

Authors

RBRenu BhardwajChandigarh UniversityPMP.K. MooreNational University of Singapore

Discussion

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Implication

Informs preclinical vascular models; leaves open translation to human endothelial function and therapy.

Structured PICO

P
Population
Isolated perfused kidney and mesentery of the rat (n=8 for dose-response experiments)
I
Intervention
Vasodilators (acetylcholine, histamine, nitroprusside) and vasoconstrictors (noradrenaline, vasopressin) with or without CHAPS (endothelial removal) or EDRF inhibitors (gossypol, metyrapone, NDGA, mepacrine, methylene blue)
C
Comparator
Control conditions without CHAPS or EDRF inhibitors
O
Outcome
Vascular resistance (vasodilatation or vasoconstriction)surrogate

This preclinical study demonstrates that endothelium-derived relaxing factor (EDRF) mediates the vasodilator response to acetylcholine and histamine in resistance blood vessels.

Cite This Study

Bhardwaj et al. (1988) studied this question.

synapsesocial.com/papers/6a83fc3320cfb2932ffe3087https://doi.org/10.1111/j.1476-5381.1988.tb11712.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for Endothelium-Dependent Vasodilation of Resistance Vessels by Acetylcholine2008 · 123 citations
  2. 2Endothelium‐derived relaxing factor inhibits<i>in vitro</i>platelet aggregation1987 · 356 citations
  3. 3Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets1987 · 819 citations
  4. 4Endothelium and the Control of Vascular Tissue1987 · 36 citations
  5. 5Absence of a Role for Superoxide Anion, Hydrogen Peroxide and Hydroxyl Radical in Endothelium-Mediated Relaxation of Rabbit Aorta2008 · 13 citations