March 1, 1990AJP Heart and Circulatory Physiology
Role of endothelium-derived relaxing factor in regulation of renal hemodynamic responses
Population
Anesthetized rats in vivo
Comparison
Intravenous infusion of acetylcholine and… vs Equihypotensive doses of prostacyclin; basal…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Animal confirmation of NO mediation in renal hemodynamics; leaves open human translation and therapeutic relevance.
Structured PICO
P
Population
Anesthetized rats in vivo
I
Intervention
Intravenous infusion of acetylcholine (ACh) and NG-monomethyl-L-arginine (L-NMMA)
C
Comparator
Equihypotensive doses of prostacyclin; basal states
O
Outcome
Hemodynamic responses (blood pressure, glomerular filtration rate, renal vasodilatation) and urinary cGMP excretionsurrogate
In vivo inhibition of nitric oxide synthesis with L-NMMA prevents acetylcholine-induced renal vasodilation and cGMP excretion, confirming NO as the endothelium-derived relaxing factor mediating these effects.
Cite This Study
Tolins et al. (1990) studied this question.