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July 1, 1990AJP Renal Physiology

Endothelium-derived relaxing factor influences renal vascular resistance

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Population

Isolated perfused kidney of the rat

Comparison

Endothelium-dependent vasodilators… vs Basal state or uninhibited state

Design

Preclinical

Authors

JRJ. RadermacherDeutsche Gesellschaft für Hämatologie und Medizinische OnkologieUFUlrich FörstermannVascular MedicineJFJürgen C. FrölichVascular Medicine

Discussion

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Implication

EDRF regulates renal vascular resistance in rats; leaves open its role in human kidney disease.

Structured PICO

P
Population
Isolated perfused kidney of the rat
I
Intervention
Endothelium-dependent vasodilators (acetylcholine, ATP), endothelium-independent vasodilators (verapamil, glyceryl trinitrate, sodium nitroprusside), and EDRF inhibitors (gossypol, methylene blue, L-NMMA, N-omega-nitro-L-arginine)
C
Comparator
Basal state or uninhibited state
O
Outcome
Renal vascular resistance (RVR)surrogate

Endothelium-derived relaxing factor (EDRF) plays an important role in the regulation of renal vascular resistance in rats.

Cite This Study

Radermacher et al. (1990) studied this question.

synapsesocial.com/papers/6a88eb48789d3eba981a210chttps://doi.org/10.1152/ajprenal.1990.259.1.f9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium‐derived relaxing factor and the effects of acetylcholine and histamine on resistance blood vessels1988 · 57 citations
  2. 2Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat1990 · 41 citations
  3. 3Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function1991 · 66 citations
  4. 4Effects of basal and acetylcholine‐induced release of endothelium‐derived relaxing factor on contraction to α‐adrenoceptor agonists in a rabbit artery and corresponding veins1990 · 31 citations
  5. 5Vasodilation Induced by Acetylcholine and by Glyceryl Trinitrate in Rat Aortic and Mesenteric Vasculature2008 · 26 citations