April 1, 1993AJP Heart and Circulatory Physiology
L-arginine analogues blunt prostaglandin-related dilation of arterioles
Population
Isolated arterioles of rat cremaster muscle
Comparison
N omega-nitro-L-arginine (L-NNA; 10, 10, and 10… vs Responses before administration of L-arginine…
Design
Preclinical
Authors
Discussion
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Implication
Reinforces NO dependence of basal tone and prostaglandin dilation in rodent arterioles; leaves open translation to human microvascular function.
Structured PICO
P
Population
Isolated arterioles of rat cremaster muscle
I
Intervention
N omega-nitro-L-arginine (L-NNA; 10(-5), 10(-4), and 10(-3) M) and N omega-monomethyl-L-arginine (L-NMMA; 10(-4) M)
C
Comparator
Responses before administration of L-arginine analogues
O
Outcome
Peak vasodilator effects of acetylcholine, sodium nitroprusside, arachidonic acid, prostaglandin E2, and adenosine, and basal diameter of arteriolessurrogate
L-arginine analogues inhibit endothelium-derived nitric oxide synthesis, blunting both basal tone and prostaglandin-related dilation in rat arterioles.
Cite This Study
Koller et al. (1993) studied this question.