September 6, 2000Clinical Science
Is l-arginine infusion an adequate tool to assess endothelium-dependent vasodilation of the human renal vasculature?
Key result
Intravenous infusion of L-arginine at 100 mg/kg increased renal plasma flow significantly more than D-arginine (+36 vs +16 ml/min; P=0.037), suggesting NO-mediated renal vasodilation.
Why the study?
Does L-arginine infusion improve renal hemodynamics compared to D-arginine in healthy male subjects?
Population
20 young, healthy male white subjects, age 26+/-2 years
Comparison
Intravenous administration of L-arginine at… vs Intravenous administration of D-arginine at…
Design
RCT, randomized cross-over, double-blind
Follow-up
30 min
Authors
Discussion
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Implication
L-arginine infusion offers a validated probe for renal endothelial function; extends evidence for NO-dependent renal vasodilation in humans.
Study Design
Type
RCT (n=20)
Blinding
Double-blind
Randomization
cross-over
Structured PICO
Does L-arginine infusion improve renal hemodynamics compared to D-arginine in healthy male subjects?
P
Population
20 young, healthy male white subjects (mean age 26 years) evaluated in a cross-over study.
I
Intervention
Intravenous administration of L-arginine at doses of 100 mg/kg body weight for 30 min or 500 mg/kg for 30 min
C
Comparator
Intravenous administration of D-arginine at doses of 100 mg/kg body weight for 30 min or 500 mg/kg for 30 min
O
Outcome
Renal plasma flow (RPF) and glomerular filtration rate (GFR)surrogate
Main Result
Absolute Event Rate: 36% vs 16%
p-value: p=0.037
L-arginine infusion at 100 mg/kg for 30 min effectively assesses endothelium-dependent vasodilation of the human renal vasculature without causing systemic hemodynamic changes.
Limitations
- No direct measurements of NO synthesis were performed
- Effects of L-arginine at 500 mg/kg need to be corrected for the effects of D-arginine before conclusions can be drawn
- no direct measurements of NO synthesis were performed
Cite This Study
Schlaich et al. (2000) conducted an RCT in Healthy (n=20). L-arginine vs. D-arginine was evaluated on Change in renal plasma flow (RPF) at 100 mg/kg dose (p=0.037). Intravenous infusion of L-arginine at 100 mg/kg increased renal plasma flow significantly more than D-arginine (+36 vs +16 ml/min; P=0.037), suggesting NO-mediated renal vasodilation.