Why the study?
Does exogenous L-arginine prevent angiotensin II-induced renal vasoconstriction in healthy subjects?
Population
17 healthy subjects (8 assigned to coinfusion study, 9 assigned to pretreatment study)
Comparison
L-arginine administered as pretreatment or… vs Placebo or Angiotensin II continuous infusion…
Design
RCT, randomized, cross-over design, double-blind
Follow-up
75 minutes (infusion period)
Authors
Loading...
Exogenous L-arginine does not blunt angiotensin II renal vasoconstriction; challenges substrate-limitation hypothesis for nitric oxide in healthy vasculature.
Does exogenous L-arginine prevent angiotensin II-induced renal vasoconstriction in healthy subjects?
Exogenous L-arginine does not counteract angiotensin II-induced renal vasoconstriction in healthy subjects, indicating that NO substrate availability is not the limiting factor for functional antagonism at the renal vasculature.
Wolzt et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: