Why the study?
Does long-term ACE inhibitor treatment restore the renal hemodynamic response to L-arginine infusion in patients with essential hypertension?
Does long-term ACE inhibitor treatment restore the renal hemodynamic response to L-arginine infusion in patients with essential hypertension?
Long-term ACE inhibitor treatment, but not other antihypertensive therapies, restores the renal vasodilator response to L-arginine in essential hypertension, suggesting a specific restorative effect on the renal nitric oxide pathway.
Answers are grounded in this paper and cite their sources.
ACEI use was associated with restored renal L-arginine response in hypertension; leaves open causal NO-pathway specificity and need for prospective trials.
We assessed the renal hemodynamic response to L-arginine infusion (30 g within 60 minutes) in normotensive subjects, patients with never-treated essential hypertension, and hypertensive patients controlled by long-term (more than 2 years) treatment with or without an angiotensin-converting enzyme inhibitor. The renal vasodilator response to L-arginine observed in normotensive subjects (15 +/- 4% increase in effective renal plasma flow) was abolished in untreated hypertensive patients and restored only in the group treated by angiotensin-converting enzyme inhibition. In the whole population a positive correlation between the change in effective renal plasma flow and the change in urinary cGMP was obtained. It is suggested that abnormalities of the renal nitric oxide pathway not corrected by increased availability of L-arginine and reversible only on long-term treatment by angiotensin-converting enzyme inhibition may underlie the abnormal renal resistance observed in essential hypertension.
No takes yet. Share an insight, caveat, or question.
Mimran et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: