Why the study?
Does L-arginine infusion affect systemic and renal hemodynamics differently in normotensive subjects, hypertensive patients with normal renal function, and hypertensive patients with renal insufficiency?
Population
69 subjects: 30 normotensive control subjects, 32 patients with mild to moderate essential hypertension and…
Comparison
L-arginine 500 mg/kg intravenously over 30 min vs Comparison between normotensive subjects…
Design
Cross-sectional
Follow-up
acute (over 30 min infusion)
Authors
Loading...
Impaired L-arginine renal response signals endothelial dysfunction in hypertension; hypothesis-generating for NO pathway modulation in renal insufficiency.
Does L-arginine infusion affect systemic and renal hemodynamics differently in normotensive subjects, hypertensive patients with normal renal function, and hypertensive patients with renal insufficiency?
The ability of the L-arginine-nitric oxide-cGMP pathway to relax renal vascular tone is impaired in essential hypertension and further blunted in patients with renal insufficiency.
Yukihito Higashi (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: