Assessment of endothelial function of the renal vasculature in human subjects
Why the study?
What is the appropriate dose and duration of action of L-arginine and L-NMMA for analyzing endothelial function of the renal vasculature in healthy subjects?
Population
29 healthy male subjects, mean age 27+/-1 years.
Comparison
L-arginine infusion with or without L-NMMA or… vs Baseline measurements and placebo co-infusion.
Authors
Discussion
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Implication
100 mg/kg L-arginine supports renal endothelial assessment in healthy subjects; prolonged effects leave open combined stimulation-blockade protocols.
Structured PICO
What is the appropriate dose and duration of action of L-arginine and L-NMMA for analyzing endothelial function of the renal vasculature in healthy subjects?
P
Population
29 healthy male subjects, mean age 27+/-1 years.
I
Intervention
L-arginine infusion (100 mg/kg and 250 mg/kg) with or without L-NMMA (4.25 mg/kg) or placebo (Protocol 1); L-NMMA followed by L-arginine 100 mg/kg (Protocol 2).
C
Comparator
Baseline measurements and placebo co-infusion.
O
Outcome
Glomerular filtration rate (GFR) and renal plasma flow (RPF) measured at rest and at the end of each infusion step.surrogate
L-arginine at 100 mg/kg is sufficient to assess renal endothelial function, but its prolonged effect alongside L-NMMA precludes testing stimulation and blockade in the same protocol.
Cite This Study
Delles et al. (2002) studied this question.