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August 1, 1993Hypertension

Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats.

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Why the study?

Do sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats?

Population

Okamoto spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats

Comparison

Acetylcholine plus N-acetylcysteine or… vs Acetylcholine alone (10 micrograms/kg per minute)

Design

Preclinical

Authors

VLVicente LaheraGeneral / Preventive / LipidsAKAli A. KhraibiKhalifa University of Science and TechnologyJRJ. Carlos RomeroMayo Clinic in Arizona

Discussion

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Implication

Hypothesis-generating in rat models; no implications for clinical hypertension management.

Structured PICO

Do sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats?

P
Population
Okamoto spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
I
Intervention
Acetylcholine (10 micrograms/kg per minute) plus N-acetylcysteine (10 micrograms/kg per minute) or thiosalicylic acid (10 micrograms/kg per minute)
C
Comparator
Acetylcholine alone (10 micrograms/kg per minute)
O
Outcome
Mean arterial pressuresurrogate

Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats, accompanied by reductions in renal function parameters.

Cite This Study

Lahera et al. (1993) studied this question.

synapsesocial.com/papers/6a7f6a00dd7040799c8b234chttps://doi.org/10.1161/01.hyp.22.2.156
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Also Consider

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  1. 1Mediatory Role of Endothelium-Derived Nitric Oxide in Renal Vasodilatory and Excretory Effects of Bradykinin1991 · 83 citations
  2. 2Reactions of cysteine with N-methyl-N-nitroso-p-toluenesulfonamide and N-methyl-N′-nitro-N-nitrosoguanidine1969 · 91 citations
  3. 3Effects of NG-monomethyl-L-arginine and L-arginine on acetylcholine renal response.1990 · 100 citations
  4. 4Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist.1989 · 93 citations
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