October 26, 2005The Journal of PhysiologyOpen Access

Nitric oxide inhibition and the impact on renal nerve‐mediated antinatriuresis and antidiuresis in the anaesthetized rat

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Population

Rats anaesthetized with chloralose-urethane, n=6 per group

Comparison

i.v. infusions of l-NAME (10 microg kg min)… vs i.v. infusion of vehicle followed by RNS

Design

Preclinical

Authors

NBNigel Mark BagnallUniversity College Cork PDPaul C. DentUniversity College Cork AWAgnieszka WalkowskaMossakowski Medical Research Institute, Polish Academy of Sciences

Discussion

Member takes

Implication

Animal data link nNOS-derived NO to renal nerve antinatriuresis; hypothesis-generating and should not yet inform clinical volume management.

Structured PICO

Population

Rats anaesthetized with chloralose-urethane, n=6 per group

Intervention

i.v. infusions of l-NAME (10 microg kg(-1) min(-1)), 1400W (20 microg kg(-1) min(-1)), or S-methyl-thiocitrulline (SMTC) (20 microg kg(-1) min(-1)) followed by low-level electrical stimulation of the renal sympathetic nerves (RNS) at 15 V, 2 ms duration, 0.5-1.0 Hz

Comparator

i.v. infusion of vehicle followed by RNS

Outcome

Changes in urine flow (UV) and sodium excretion (U(Na)V)surrogate

Renal nerve-mediated antinatriuresis and antidiuresis is dependent on the presence of nitric oxide, generated in part by neuronal NOS.

Cite This Study

Bagnall et al. (2005) studied this question.

synapsesocial.com/papers/6a8261295a62cdcac13f1bb7 https://doi.org/10.1113/jphysiol.2005.097709

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Implication

Animal data link nNOS-derived NO to renal nerve antinatriuresis; hypothesis-generating and should not yet inform clinical volume management.

Nitric oxide inhibition and the impact on renal nerve‐mediated antinatriuresis and antidiuresis in the anaesthetized rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric oxide inhibition and the impact on renal nerve‐mediated antinatriuresis and antidiuresis in the anaesthetized rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider