Key result
Renal denervation decreased mean arterial blood pressure and renin secretion, but neither denervation nor nNOS inhibition affected the natriuretic response to acute sodium loading.
Why the study?
Does renal denervation and nNOS inhibition affect renin secretion and natriuresis following acute sodium loading in conscious rats?
Population
Conscious, catheterized rats
Comparison
Chronic renal denervation with and without nNOS… vs Control rats (intact renal nerves, no SMTC)
Design
Preclinical
Follow-up
2 hours (acute loading) and first days after denervation
Authors
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Findings in this animal model should not yet change practice; leaves open RSNA/nNOS roles in human sodium handling.
Does renal denervation and nNOS inhibition affect renin secretion and natriuresis following acute sodium loading in conscious rats?
Absolute Event Rate: 14.5% vs 19.3%
p-value: p=<0.005
Acute sodium-driven renin regulation and natriuresis appear independent of renal sympathetic nerve activity and nNOS in conscious rats.
Kompanowska‐Jezierska et al. (2008) studied this question. Renal denervation with and without nNOS inhibition by SMTC vs. Control was evaluated on Plasma renin concentration (PRC) (p=<0.005). Renal denervation decreased mean arterial blood pressure and renin secretion, but neither denervation nor nNOS inhibition affected the natriuretic response to acute sodium loading.
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