February 1, 1996Journal of Cardiovascular Pharmacology

Effect of Sodium Nitroprusside on Norepinephrine Overflow and Antidiuresis Induced by Stimulation of Renal Nerves in Anesthetized Dogs

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Why the study?

Does sodium nitroprusside alter norepinephrine overflow and antidiuresis induced by renal nerve stimulation in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Intrarenal arterial infusion of sodium… vs Renal nerve stimulation alone or with NOARG alone

Design

Preclinical

Authors

HMHitoshi MaekawaNational Defense Medical College YMYasuo MatsumuraAmerican Pharmacists Association GMGen MatsuoOsaka University of Pharmaceutical Sciences

Discussion

Member takes

Implication

Preclinical data support nitric oxide modulating renal sympathetic neurotransmission in dogs; leaves open human translation.

Structured PICO

Does sodium nitroprusside alter norepinephrine overflow and antidiuresis induced by renal nerve stimulation in anesthetized dogs?

Population

Anesthetized dogs

Intervention

Intrarenal arterial infusion of sodium nitroprusside (SNP) 1 µg/kg/min during low-frequency renal nerve stimulation (0.5-2.0 Hz), with or without NO synthase inhibitor NG-nitro-L-arginine (NOARG) 40 µg/kg/min

Comparator

Renal nerve stimulation alone or with NOARG alone

Outcome

Norepinephrine secretion rate (NESR), urine flow (UF), urinary excretion of sodium (UNaV), and fractional excretion of sodium (FENa)surrogate

Endogenous nitric oxide acts as an inhibitory modulator of renal noradrenergic neurotransmission at the prejunctional level, regulating renal function.

Cite This Study

Maekawa et al. (1996) studied this question.

synapsesocial.com/papers/6a20de4534bef10fdaeb15ce https://doi.org/10.1097/00005344-199602000-00006

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Effect of Sodium Nitroprusside on Norepinephrine Overflow and Antidiuresis Induced by Stimulation of Renal Nerves in Anesthetized Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Sodium Nitroprusside on Norepinephrine Overflow and Antidiuresis Induced by Stimulation of Renal Nerves in Anesthetized Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider