March 1, 1998AJP Renal Physiology

Neuronal nitric oxide synthase modulates rat renal microvascular function

View Full Paper

Ask AI

Bookmark

Population

Afferent and efferent arterioles of kidneys harvested from male Sprague-Dawley rats

Comparison

Superfusion with specific nNOS inhibitor… vs Control conditions

Design

Preclinical

Authors

AIAtsuhiro IchiharaGeneral / Preventive / Lipids EIEdward W. InschoUniversity of Alabama at Birmingham JIJohn D. ImigVascular Medicine

Discussion

Member takes

Implication

No clinical translation from rat arteriolar data; leaves open nNOS role in human renal ANG II responses.

Structured PICO

Population

Afferent (21.2 +/- 0.2 microns) and efferent (18.5 +/- 0.2 microns) arterioles of kidneys harvested from male Sprague-Dawley rats

Intervention

Superfusion with specific nNOS inhibitor S-methyl-L-thiocitrulline (L-SMTC) or nonselective NOS inhibitor N omega-nitro-L-arginine (L-NNA), with or without acetazolamide or angiotensin II

Comparator

Control conditions (e.g., before papillectomy, without acetazolamide, or without ANG II)

Outcome

Afferent and efferent arteriolar diameterssurrogate

Neuronal nitric oxide synthase modulates afferent arteriolar tone dependent on distal tubular fluid flow and enhances efferent arteriolar responsiveness to angiotensin II in rat kidneys.

Cite This Study

Ichihara et al. (1998) studied this question.

synapsesocial.com/papers/6a20aee88e09200678d114dd https://doi.org/10.1152/ajprenal.1998.274.3.f516

View Full Paper

Ask AI

Bookmark

Neuronal nitric oxide synthase modulates rat renal microvascular function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neuronal nitric oxide synthase modulates rat renal microvascular function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider