Key result
In 2K1C hypertensive rats, nNOS expression was increased 1.7-fold in clipped and 3-fold in non-clipped kidneys compared to sham, which was normalized by losartan but did not increase enzyme activity.
In a rat model of renovascular hypertension, AT1 receptors and oxidative stress are primary stimuli for increased renal nNOS expression, though this upregulation does not translate to higher enzyme activity.
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Losartan normalizes renal nNOS expression in this rat model without raising activity; leaves open relevance to human renovascular hypertension.
Pereira et al. (2009) studied Renovascular hypertension (n=38). Losartan or tempol vs. Sham-operated and untreated 2K1C rats was evaluated on nNOS expression in kidneys. In 2K1C hypertensive rats, nNOS expression was increased 1.7-fold in clipped and 3-fold in non-clipped kidneys compared to sham, which was normalized by losartan but did not increase enzyme activity.
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