January 1, 1996Hypertension

Nitric Oxide and the Depressor Response to Angiotensin Blockade in Hypertension

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Why the study?

Does nitric oxide synthesis inhibition attenuate the blood pressure reduction caused by renin-angiotensin system blockade in hypertensive rats?

Population

Rats made hypertensive by coarctation of the aorta between the renal arteries or by long-term infusion of…

Comparison

Angiotensin-converting enzyme inhibitor… vs Ramiprilat or losartan without…

Design

Preclinical

Follow-up

short-term

Authors

HGHui GuanQingdao University VCVictoria CachofeiroUniversidad Complutense de Madrid MPMichael L. PucciUniversity of California, Los Angeles

Discussion

Member takes

Implication

Nitric oxide may mediate acute BP effects of RAS blockade in rat models; leaves open human relevance and requires clinical confirmation.

Structured PICO

Does nitric oxide synthesis inhibition attenuate the blood pressure reduction caused by renin-angiotensin system blockade in hypertensive rats?

Population

Rats made hypertensive by coarctation of the aorta between the renal arteries or by long-term infusion of angiotensin II

Intervention

Angiotensin-converting enzyme inhibitor ramiprilat (2 mg/kg IV) or angiotensin II antagonist losartan (30 mg/kg IV) with pretreatment with NG-nitro-L-arginine methyl ester (10 mg/kg IV) to inhibit nitric oxide synthesis

Comparator

Ramiprilat or losartan without NG-nitro-L-arginine methyl ester pretreatment

Outcome

Short-term blood pressure reductionsurrogate

Nitric oxide contributes significantly to the short-term blood pressure reduction caused by interruption of the renin-angiotensin system in angiotensin-dependent hypertension models.

Cite This Study

Guan et al. (1996) studied this question.

synapsesocial.com/papers/6a7cc324273accedbda8b38d https://doi.org/10.1161/01.hyp.27.1.19

Topics

Hypertension management

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Nitric Oxide and the Depressor Response to Angiotensin Blockade in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Nitric Oxide and the Depressor Response to Angiotensin Blockade in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider