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February 1, 1995American Journal of Hypertension

Renal hypertensive angiopathyComparison between chronic NO suppression and DOCA-salt intoxication

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Population

Wistar rats

Comparison

NG-nitro-L-arginine methyl ester induced… vs 11-desoxycorticosterone plus salt intake induced…

Design

Preclinical

Follow-up

7 weeks

Authors

JAJean‐François ArnalUniversité Toulouse III - Paul SabatierNHN HinglaisHôpital Necker-Enfants MaladesMAMarie–Dominique AppayCentre National de la Recherche Scientifique

Discussion

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Implication

Suggests model-specific renal vascular injury despite equal BP; leaves open RAS-NO pathways in human nephroangiosclerosis.

Structured PICO

P
Population
Wistar rats
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME) induced hypertension (chronic NO suppression)
C
Comparator
11-desoxycorticosterone plus salt intake (DOCA-salt) induced hypertension and normotensive controls
O
Outcome
Development of renal angiopathy (nephroangiosclerosis) and left ventricular hypertrophy (LVH)surrogate

Activation of the renin-angiotensin system specifically participates in the development of nephroangiosclerosis and left ventricular hypertrophy during chronic NO synthase blockade in hypertensive rats.

Cite This Study

Arnal et al. (1995) studied this question.

synapsesocial.com/papers/6a89425fa176018d404319aehttps://doi.org/10.1016/0895-7061(94)00179-f
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition.1993 · 200 citations
  2. 2Endothelium-derived relaxing factor regulates renin release in vivo1992 · 90 citations
  3. 3Role of endothelium-derived nitric oxide in the regulation of blood pressure.1989 · 1,838 citations
  4. 4Relation of plasma renin to end organ damage and to protection of K+ feeding in stroke-prone hypertensive rats.1990 · 123 citations
  5. 5Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators1989 · 165 citations