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June 1, 1998American Journal of Hypertension

Antihypertensive Agents Prevent Nephrosclerosis and Left Ventricular Hypertrophy Induced in Rats by Prolonged Inhibition of Nitric Oxide Synthesis

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Why the study?

Does imidapril or amlodipine prevent nephrosclerosis and left ventricular hypertrophy in rats with L-NAME-induced hypertension?

Population

Male Wistar rats with hypertension induced by chronic inhibition of nitric oxide synthesis via L-NAME

Comparison

Imidapril 10 mg/L or 100 mg/L, or amlodipine 50… vs Distilled water and L-NAME alone

Design

Preclinical

Follow-up

6 weeks

Authors

NANobuhiro AkuzawaGunma Chuo HospitalTNTakuji NakamuraJGC (Japan)TKTOSHINARI KURASHINAGunma University

Discussion

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Implication

Imidapril's superiority in this rat model should not guide therapy; leaves open differential ACEI versus CCB effects on LVH and albuminuria in humans.

Structured PICO

Does imidapril or amlodipine prevent nephrosclerosis and left ventricular hypertrophy in rats with L-NAME-induced hypertension?

P
Population
Male Wistar rats (n=10-12 per group) with hypertension induced by chronic inhibition of nitric oxide synthesis via L-NAME
I
Intervention
Imidapril 10 mg/L or 100 mg/L, or amlodipine 50 mg/L or 100 mg/L in drinking water for 6 weeks
C
Comparator
Distilled water (control) and L-NAME alone (500 mg/L)
O
Outcome
Prevention of nephrosclerosis and left ventricular hypertrophy (measured by area of left ventricular wall and histology)surrogate

In a rat model of NO-inhibition-induced hypertension, ACE inhibition with imidapril was more effective than calcium channel blockade with amlodipine in preventing nephrosclerosis and left ventricular hypertrophy.

Cite This Study

Akuzawa et al. (1998) studied this question.

synapsesocial.com/papers/6a7c7a0d502bfbc401fd639ehttps://doi.org/10.1016/s0895-7061(98)00051-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ACE Inhibition Prevents and Reverses L-NAMEExacerbated Nephrosclerosis in Spontaneously Hypertensive Rats1996 · 64 citations
  2. 2Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition.1993 · 200 citations
  3. 3Comparison of Effect of Endothelin Antagonism and Angiotensin-Converting Enzyme Inhibition on Blood Pressure and Vascular Structure in Spontaneously Hypertensive Rats Treated WithNω-Nitro- l -Arginine Methyl Ester1996 · 36 citations
  4. 4Renal hypertensive angiopathyComparison between chronic NO suppression and DOCA-salt intoxication1995 · 35 citations
  5. 5Release of nitric oxide in response to acetylcholine is unaltered in spontaneously hypertensive rats1994 · 44 citations