June 1, 1999AJP Heart and Circulatory Physiology

PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries

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Population

One-kidney, one-clip (1K1C) hypertensive rats (n=8) and uninephrectomized controls (n=8)

Comparison

Renal artery stenosis (1K1C model) vs Uninephrectomized controls

Design

Preclinical

Follow-up

14 days

Authors

ADAnca D. DobrianEastern Virginia Medical School SWSuzanne S. WadeEastern Virginia Medical School RPRussell L. PrewittLouisiana State University

Discussion

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Implication

Supports PDGF-A role in rat hypertensive hypertrophy; hypothesis-generating and should not yet change practice.

Structured PICO

Population

One-kidney, one-clip (1K1C) hypertensive rats (n=8) and uninephrectomized controls (n=8)

Intervention

Renal artery stenosis (1K1C model)

Comparator

Uninephrectomized controls

Outcome

Level of PDGF-A and -B mRNA and protein in the wall of large and small arteries, and morphological measurement of arterial hypertrophysurrogate

In a non-renin-dependent rat model of hypertension, elevated blood pressure directly correlates with increased PDGF-A synthesis and vascular hypertrophy.

Cite This Study

Dobrian et al. (1999) studied this question.

synapsesocial.com/papers/6a6f9bd85d37378ac1dcab34 https://doi.org/10.1152/ajpheart.1999.276.6.h2159

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PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider