Key result
Angiotensin II produces a biphasic effect on proximal tubular Na+,K+-ATPase activity via AT1 receptors, involving PTx-sensitive inhibition of adenylyl cyclase and stimulation of PLA2.
Angiotensin II exerts a biphasic effect on proximal tubular Na+,K+-ATPase activity via AT1 receptors, utilizing distinct signaling pathways for stimulation and inhibition.
No takes yet. Share an insight, caveat, or question.
Caution against human extrapolation in hypertension; extends AT1 signaling insights in animal renal models.
Bharatula et al. (1998) studied this question. Angiotensin II was evaluated on Proximal tubular Na+,K+-ATPase activity and cAMP accumulation. Angiotensin II produces a biphasic effect on proximal tubular Na+,K+-ATPase activity via AT1 receptors, involving PTx-sensitive inhibition of adenylyl cyclase and stimulation of PLA2.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: