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Two ion channels, a large Ca(2+)-activated K(+) channel (BK) and a store-operated Ca(2+) channel (SOCC), have been defined in glomerular mesangial cells with respect to structure and function.
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This review summarizes the molecular structure and function of BK and SOCC ion channels in glomerular mesangial cells.
Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca(2+)-activated K(+) channel (BK) and a store-operated Ca(2+) channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming alpha-subunit and an accessory beta1-subunit, operate as Ca(2+)-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily.
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Ma et al. (2005) conducted a review in Ion channels in glomerular mesangial cells. Two ion channels, a large Ca(2+)-activated K(+) channel (BK) and a store-operated Ca(2+) channel (SOCC), have been defined in glomerular mesangial cells with respect to structure and function.
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