Key result
Large-conductance calcium-activated potassium (BK) channels play vital roles in glomerular podocytes and mesangial cells, and their specific subtypes represent potential therapeutic targets for glomerular diseases.
This review highlights the physiological and pathological roles of BK channels in the glomerulus, emphasizing their importance in renal function.
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BK channel roles in podocytes and mesangial cells may guide glomerular research; leaves open therapeutic targeting pending clinical studies.
Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.
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Tao et al. (2016) conducted a review in Glomerular disease. BK channel modulators was evaluated. Large-conductance calcium-activated potassium (BK) channels play vital roles in glomerular podocytes and mesangial cells, and their specific subtypes represent potential therapeutic targets for glomerular diseases.
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