Activation of cGMP-dependent Protein Kinase by Protein Kinase C

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Population

HEK-293 cells and in vitro purified components

Design

Preclinical

Authors

Discussion

No immediate clinical implications; leaves open whether this PKC-PKG pathway operates in cardiovascular disease models.

Population

HEK-293 cells and in vitro purified components

Intervention

Phorbol 12-myristate 13-acetate (PMA) stimulation and site-directed mutagenesis (T58E, T58A)

Outcome

PKG1alpha phosphorylation and activation (measured by vasodilator-stimulated phosphoprotein phosphorylation and in vitro kinase assays)surrogate

This study identifies a novel cyclic nucleotide-independent mechanism for PKG activation via PKC-dependent phosphorylation.

Hou et al. (2003) studied this question.

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