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September 1, 2001Journal of Applied Physiology

Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression

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Population

Smooth muscle cells and vascular smooth muscle cells (VSMCs)

Design

Review

Authors

TLThomas LincolnNorthwestern UniversityNDNupur B. DeyUSA Mitchell Cancer InstituteHSHassan SellakEmory University

Discussion

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Implication

Should not change clinical practice; hypothesis-generating for NO/cGMP/PKG pathway targeting in fibroproliferative vascular disease.

Structured PICO

P
Population
Smooth muscle cells and vascular smooth muscle cells (VSMCs)
I
Intervention
cGMP-dependent protein kinase (PKG) signaling pathway
O
Outcome
Regulation of contractile tone and gene expression (phenotypic modulation)

The nitric oxide/cGMP/PKG pathway regulates both contractile tone and gene expression in vascular smooth muscle cells, highlighting its potential role in the pathogenesis of fibroproliferative vascular diseases.

Cite This Study

Lincoln et al. (2001) studied this question.

synapsesocial.com/papers/6a77366ea7498e5110ae63dchttps://doi.org/10.1152/jappl.2001.91.3.1421
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin1995 · 118 citations
  2. 2Prostacyclin and Sodium Nitroprusside Inhibit the Activity of the Platelet Inositol 1,4,5-Trisphosphate Receptor and Promote Its Phosphorylation1996 · 149 citations
  3. 3Modulation of Transcription Factor Sp1 by cAMP-dependent Protein Kinase1997 · 208 citations
  4. 4Two Sp1-binding Sites Mediate cAMP-induced Transcription of the Bovine CYP11A Gene through the Protein Kinase A Signaling Pathway1995 · 95 citations
  5. 5Rising behind NO: cGMP-dependent protein kinases2000 · 340 citations