Key result
Recent advances highlight the mechanisms of transcriptional and post-transcriptional regulation of PKG-I expression in vascular smooth muscle cells and its role in cardiovascular diseases.
Population
Vascular smooth muscle cells (VSMCs) in the context of cardiovascular diseases and vascular injury
Design
Review
Authors
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May inform PKG-I targeted therapies in vascular disease; leaves open clinical validation in prospective trials.
This review highlights the mechanisms of PKG-I down-regulation in vascular smooth muscle cells and its role in vascular injury and cardiovascular diseases.
Sellak et al. (2012) conducted a review in Cardiovascular diseases. PKG-I regulation was evaluated. Recent advances highlight the mechanisms of transcriptional and post-transcriptional regulation of PKG-I expression in vascular smooth muscle cells and its role in cardiovascular diseases.
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