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June 13, 2016Cardiovascular ResearchOpen Access

Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G

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Key result

Modulation of cGMP-PKG has entered clinical practice for pulmonary hypertension and erectile dysfunction, but translation to clinical success in heart failure has failed thus far.

Design

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Authors

PRPeter P. RainerDKDavid A. Kass

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Overview

Cautions against premature PKG-based HF therapies; leaves open optimized translation strategies.

PICO

P
Population
Heart failure and cardiovascular disease
I
Intervention / Comparator
cGMP-PKG modulation

Understanding novel non-canonical roles of PKG1 is necessary for successful clinical translation of cGMP-PKG modulation therapies in heart failure.

Cite This Study

Rainer et al. (2016) conducted a review in Heart failure and cardiovascular disease. cGMP-PKG modulation was evaluated. Modulation of cGMP-PKG has entered clinical practice for pulmonary hypertension and erectile dysfunction, but translation to clinical success in heart failure has failed thus far.

synapsesocial.com/papers/6a6d3d8335aa2c282cdfd676https://doi.org/10.1093/cvr/cvw107
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